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ISSN 0973 - 0958
INSULIN THERAPY
The Insulins available now are the "pure" varieties and contain negligible risks of immunogenicity. These are of four types - beef, porcine, mixed and human insulin
Beef insulin differs from human insulin in three amino acids,
namely A8, A 10 and B 30.
Porcine insulin differs from human insulin in only one amino
acid i.e. B30 position. Thus, porcine insulin is less immunogenic
than beef insulin.
Mixed insulin contains a mixture of bovine and porcine insulin
and it is more antigenic than single species
Human insulin is pure and has the same amino acid structure
as that of native insulin. They are made by genetic engineering
or by transformation from porcine insulin by substituting alanine
with threonine in the B30 position.
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